Source:http://linkedlifedata.com/resource/pubmed/id/20545459
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2011-3-14
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pubmed:abstractText |
The present investigation was aimed to develop and explore the use of chondroitin sulfate-coupled liposomes (CS-LP) for solid tumor targeting. The liposomes were prepared by cast film method and coupled with chondroitin sulfate. The coupling was confirmed by infrared spectroscopy. They were further characterized for various parameters such as vesicle shape and surface morphology, size and size distribution, zeta potential, entrapment efficiency, and in vitro release pattern. The vesicle size of the uncoupled liposome (256?nm) was found to be less than that of CS-LP (310?nm). In vitro drug release exhibited a release of 44.2% from uncoupled liposomal formulation, compared to 38.3% as observed in coupled formulation at the end of 24?hr. The uptake of the CS-LP and uncoupled liposomes by MDA-MB-231 breast cancer cell lines was visualized using fluorescence microscopy that revealed the dependence of liposomes recognition and higher uptake on the coupling of chondroitin sulfate. Coupling of the liposomes significantly enhanced the tumor uptake of drug, which is reflected in the recovery of a higher percentage of the dose from tumor following administration of CS-LP in comparison to uncoupled liposomes or free drug, suggesting that they can be used as vectors for solid tumor targeting.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfates,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1029-2330
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-7
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pubmed:meshHeading |
pubmed-meshheading:20545459-Animals,
pubmed-meshheading:20545459-Antineoplastic Agents,
pubmed-meshheading:20545459-Breast Neoplasms,
pubmed-meshheading:20545459-Cell Line, Tumor,
pubmed-meshheading:20545459-Chondroitin Sulfates,
pubmed-meshheading:20545459-Drug Carriers,
pubmed-meshheading:20545459-Drug Delivery Systems,
pubmed-meshheading:20545459-Etoposide,
pubmed-meshheading:20545459-Female,
pubmed-meshheading:20545459-Humans,
pubmed-meshheading:20545459-Liposomes,
pubmed-meshheading:20545459-Mice,
pubmed-meshheading:20545459-Mice, Inbred BALB C,
pubmed-meshheading:20545459-Neoplasms, Experimental,
pubmed-meshheading:20545459-Tissue Distribution
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pubmed:year |
2011
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pubmed:articleTitle |
Chondroitin sulfate functionalized liposomes for solid tumor targeting.
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pubmed:affiliation |
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar (Madhya Pradesh), India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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