Source:http://linkedlifedata.com/resource/pubmed/id/20545387
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2010-6-15
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pubmed:abstractText |
Cocaine dependence is associated with neuroadaptations in stress and reward pathways that could alter stress and drug-related experiences and associated interoceptive sensations and result in enhanced craving states. Subjective interoceptive emotional and physiological responses experienced in stressful and drug cue situations were examined in abstinent cocaine-dependent individuals. Fifty-six treatment engaged cocaine-dependent patients with comorbid alcohol abuse or dependence were interviewed to identify personal stressful, drug cue, and neutral situations using a scene construction questionnaire (SCQ) that includes an emotional and physiological response checklist. Using this checklist, subjects identified emotional and bodily sensations that they recently experienced in the stress- and drug-related scenarios. Kappa coefficients indicated fair to moderate but significant degree of concordance in heart (p < .01), perspiration (p < .05), stomach (p < .05), and blood flow (p < .01) sensations for both stress and drug cue scenarios, while the McNemar change test indicated differential endorsement of interoceptive responses in stress and drug cue situations for breathing (p < .05), stomach (p < .05), tension (p < .05), and chest (p < .05) sensations, and for sad (p < .01), anger (p < .01), and excitement (p < .01) responses. Increased heartbeat and tension, tears, and anger urges were most commonly endorsed in the stress scenarios (between 50% and 79%), whereas butterflies in stomach, increased heartbeat and tension, jittery, restless, and warm excitement (53%-73%) were the most frequently endorsed sensations in the drug cue-related experiences. These self-reported sensations comprise both general arousal and specific interoceptive responses pertaining to stress or drug cue-related experiences in cocaine dependence, with potential value in guiding treatments targeting craving reduction.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1936-2293
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
229-37
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pubmed:meshHeading |
pubmed-meshheading:20545387-Adult,
pubmed-meshheading:20545387-Alcoholism,
pubmed-meshheading:20545387-Autonomic Nervous System,
pubmed-meshheading:20545387-Checklist,
pubmed-meshheading:20545387-Cocaine-Related Disorders,
pubmed-meshheading:20545387-Female,
pubmed-meshheading:20545387-Heart Rate,
pubmed-meshheading:20545387-Humans,
pubmed-meshheading:20545387-Male,
pubmed-meshheading:20545387-Middle Aged,
pubmed-meshheading:20545387-Questionnaires,
pubmed-meshheading:20545387-Self Disclosure,
pubmed-meshheading:20545387-Sensation,
pubmed-meshheading:20545387-Stress, Psychological,
pubmed-meshheading:20545387-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Self-reports of interoceptive responses during stress and drug cue-related experiences in cocaine- and alcohol-dependent individuals.
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pubmed:affiliation |
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. keri.bergquist@yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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