Linked Life Data

20538795

Source:http://linkedlifedata.com/resource/pubmed/id/20538795

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-9-17
pubmed:databankReference
pubmed:abstractText
Patients with systemic lupus erythematosus (SLE) have a markedly increased risk to develop cardiovascular disease, and traditional cardiovascular risk factors fail to account for this increased risk. We used microarray to probe the platelet transcriptome in patients with SLE and healthy controls, and the gene and protein expression of a subset of differentially expressed genes was further investigated and correlated to platelet activation status. Real-time PCR was used to confirm a type I interferon (IFN) gene signature in patients with SLE, and the IFN-regulated proteins PRKRA, IFITM1 and CD69 (P < .0001) were found to be up-regulated in platelets from SLE patients compared with healthy volunteers. Notably, patients with a history of vascular disease had increased expression of type I IFN-regulated proteins as well as more activated platelets compared with patients without vascular disease. We suggest that interferogenic immune complexes stimulate production of IFN? that up-regulates the megakaryocytic type I IFN-regulated genes and proteins. This could affect platelet activation and contribute to development of vascular disease in SLE. In addition, platelets with type I IFN signature could be a novel marker for vascular disease in SLE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1951-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20538795-Adult, pubmed-meshheading:20538795-Aged, pubmed-meshheading:20538795-Aged, 80 and over, pubmed-meshheading:20538795-Antigens, CD, pubmed-meshheading:20538795-Antigens, Differentiation, pubmed-meshheading:20538795-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:20538795-Blood Platelets, pubmed-meshheading:20538795-Blotting, Western, pubmed-meshheading:20538795-Cohort Studies, pubmed-meshheading:20538795-Female, pubmed-meshheading:20538795-Gene Expression Profiling, pubmed-meshheading:20538795-Humans, pubmed-meshheading:20538795-Interferon Type I, pubmed-meshheading:20538795-Lectins, C-Type, pubmed-meshheading:20538795-Lupus Erythematosus, Systemic, pubmed-meshheading:20538795-Male, pubmed-meshheading:20538795-Membrane Proteins, pubmed-meshheading:20538795-Middle Aged, pubmed-meshheading:20538795-Proteomics, pubmed-meshheading:20538795-RNA-Binding Proteins, pubmed-meshheading:20538795-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:20538795-Up-Regulation, pubmed-meshheading:20538795-Vascular Diseases, pubmed-meshheading:20538795-Young Adult
pubmed:year
2010
pubmed:articleTitle
Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease.
pubmed:affiliation
Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University Hospital, Sölvegatan 23, Lund, Sweden. christian.lood@med.lu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't