Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
32
pubmed:dateCreated
2010-8-2
pubmed:abstractText
NELL2 (neural tissue-specific epidermal growth factor-like repeat domain-containing protein) is a secreted glycoprotein that is predominantly expressed in neural tissues. We reported previously that NELL2 mRNA abundance in brain is increased by estrogen (E2) treatment and that NELL2 is involved in the E2-dependent organization of a sexually dimorphic nucleus in the preoptic area. In this study we cloned the mouse NELL2 promoter and found it to contain two half-E2 response elements. Electrophoretic mobility shift assays and promoter assays showed that E2 and its receptors (ERalpha and ERbeta) stimulated NELL2 transcription by binding to the two half-E2 response elements. Hippocampal neuroprogenitor HiB5 cells expressing recombinant NELL2 showed increased cell survival under cell death-inducing conditions. Blockade of endogenous synthesis of NELL2 in HiB5 cells abolished the cell survival effect of E2 and resulted in a decrease in phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2). These data suggest that the NELL2 gene is trans-activated by E2 and contributes to mediating the survival promoting effects of E2 via intracellular signaling pathway of ERK.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-10328986, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-10342835, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-10600492, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-10719225, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-10792583, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-11040417, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-11250935, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-11452016, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-11459795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-11750068, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12122016, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12145337, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12153491, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12472893, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12488359, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-12941464, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-1497677, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-15183717, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-1652060, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-17126425, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-1737365, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-18195084, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-18513367, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-18547942, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-18677093, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-1878969, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-2019605, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-2041787, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-2467742, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-2850481, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-2991899, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-3614201, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-3908433, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-6313230, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-7488136, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-7585542, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-7655083, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-7729800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-7804599, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-8106522, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-8264580, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-8896803, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-8975702, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-8987774, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-9721933, http://linkedlifedata.com/resource/pubmed/commentcorrection/20538601-9931121
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1083-351X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25074-84
pubmed:dateRevised
2011-8-25
pubmed:meshHeading
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