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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-7-26
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pubmed:abstractText |
Inherited arrhythmias can be caused by mutations in the cardiac ryanodine receptor (RyR2). The cellular source of these arrhythmias is unknown. Isolated RyR2(R4496C) mouse ventricular myocytes display arrhythmogenic activity related to spontaneous Ca(2+) release during diastole. On the other hand, recent whole-heart epicardial and endocardial optical mapping data demonstrate that ventricular arrhythmias in the RyR2(R4496C) mouse model of catecholaminergic polymorphic ventricular tachycardia (CPVT) originate in the His-Purkinje system, suggesting that Purkinje cells, and not ventricular myocytes, may be the cellular source of arrhythmogenic activity. The relative effect of the RyR2(R4496C) mutation on calcium homeostasis in ventricular myocytes versus Purkinje cells is unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-10700450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-11157710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-11208676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-11509449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-12093772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-12106942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-12169647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-12618230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-15194464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-15322274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-15890976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-15947247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-16825580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-17119150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-17429038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-17872467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-19096022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-19939742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-5645545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-7074728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20538074-7867192
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1556-3871
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1122-8
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:20538074-Animals,
pubmed-meshheading:20538074-Calcium,
pubmed-meshheading:20538074-Calcium Metabolism Disorders,
pubmed-meshheading:20538074-Disease Models, Animal,
pubmed-meshheading:20538074-Green Fluorescent Proteins,
pubmed-meshheading:20538074-Mice,
pubmed-meshheading:20538074-Mice, Transgenic,
pubmed-meshheading:20538074-Myocytes, Cardiac,
pubmed-meshheading:20538074-Purkinje Cells,
pubmed-meshheading:20538074-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:20538074-Tachycardia, Ventricular
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pubmed:year |
2010
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pubmed:articleTitle |
Purkinje cell calcium dysregulation is the cellular mechanism that underlies catecholaminergic polymorphic ventricular tachycardia.
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pubmed:affiliation |
Center for Arrhythmia Research, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48108, USA. toddherr@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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