Source:http://linkedlifedata.com/resource/pubmed/id/20538031
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2010-8-27
|
| pubmed:abstractText |
Interleukin-1 receptor antagonist (IL-1Ra) is a good indicator of disease activity in patients with systemic lupus erythematosus (SLE). Glucocorticosteroids are the most frequently used drugs in SLE. Our goal was to compare IL-1Ra activity in SLE patients with and without renal involvement and to determine the effect of different dosage of glucocorticosteroids used in 17 patients with active SLE without nephritis, 7 patients with inactive lupus nephritis (LN), and 8 patients with active LN, along with 10 healthy controls. IL-1Ra levels were measured in the serum of SLE patients by Human Luminex [100] analyzer. Both in patients with active SLE without nephritis and in patients with LN, serum levels of IL-1Ra (p<0.001) were significantly higher compared with those in the controls. IL-1Ra was significantly higher in patients with active LN than in patients with inactive LN (p = 0.028). The use of methylprednisolone was significantly higher in the active LN group compared with the inactive LN group (p = 0.013). SLE patients with higher IL-1Ra are at lower risk for developing nephritis. The higher doses of glucocorticosteroids needed in active LN could be due to steroid resistance and IL-1Ra polymorphism. Measurement of IL-1Ra levels in SLE patients could help to predict future renal involvement.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Methylprednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Glycoprotein I
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1879-1166
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
874-7
|
| pubmed:meshHeading |
pubmed-meshheading:20538031-Adult,
pubmed-meshheading:20538031-Biological Markers,
pubmed-meshheading:20538031-C-Reactive Protein,
pubmed-meshheading:20538031-Creatinine,
pubmed-meshheading:20538031-Cyclophosphamide,
pubmed-meshheading:20538031-Cyclosporine,
pubmed-meshheading:20538031-Female,
pubmed-meshheading:20538031-Glomerular Filtration Rate,
pubmed-meshheading:20538031-Humans,
pubmed-meshheading:20538031-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:20538031-Lupus Erythematosus, Systemic,
pubmed-meshheading:20538031-Lupus Nephritis,
pubmed-meshheading:20538031-Male,
pubmed-meshheading:20538031-Metabolic Clearance Rate,
pubmed-meshheading:20538031-Methylprednisolone,
pubmed-meshheading:20538031-Middle Aged,
pubmed-meshheading:20538031-Proteinuria,
pubmed-meshheading:20538031-Severity of Illness Index,
pubmed-meshheading:20538031-Young Adult,
pubmed-meshheading:20538031-beta 2-Glycoprotein I
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease.
|
| pubmed:affiliation |
3rd Department of Internal Medicine, Division of Clinical Immunology, Medical and Health Science Center of University of Debrecen, Debrecen, Hungary.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|