Source:http://linkedlifedata.com/resource/pubmed/id/20538028
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2010-8-27
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| pubmed:abstractText |
Accumulated evidence suggested that cytotoxic T-lymphocyte antigen 4 (CTLA4) plays an important role in the negative regulation of T-cell proliferation and activation, and thus participates in antitumor immunity and cancer surveillance. Previously we reported that the CTLA4 49A/G (rs231775) single nucleotide polymorphism (SNP) was a candidate cancer susceptibility marker for breast, lung, esophageal, and gastric cancers. In the present study, we expanded our study to two infection-related cancers, namely, hepatocellular carcinoma (HCC) and cervical cancer. We genotyped rs231775 in two independent case-control studies of 864 HCC patients and 864 control subjects, and 719 cervical cancer patients and 719 control subjects. In the multivariate logistic regression models, CTLA4 +49 A/G variant genotype was associated with increased risk (AA vs GG) by 1.43-fold (95% CI = 0.94-2.17) for HCC, and 1.66-fold (95% CI = 1.13-2.44) for cervical cancer. Taken together, the results suggest that CTLA4 rs231775 may serve as a common cancer susceptibility marker.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1879-1166
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
71
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
888-91
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20538028-Adult,
pubmed-meshheading:20538028-Age Factors,
pubmed-meshheading:20538028-Aged,
pubmed-meshheading:20538028-Alcohol Drinking,
pubmed-meshheading:20538028-Antigens, CD,
pubmed-meshheading:20538028-CTLA-4 Antigen,
pubmed-meshheading:20538028-Carcinoma, Hepatocellular,
pubmed-meshheading:20538028-Carcinoma, Squamous Cell,
pubmed-meshheading:20538028-China,
pubmed-meshheading:20538028-Female,
pubmed-meshheading:20538028-Gene Frequency,
pubmed-meshheading:20538028-Genetic Predisposition to Disease,
pubmed-meshheading:20538028-Genotype,
pubmed-meshheading:20538028-Hepatitis B,
pubmed-meshheading:20538028-Hepatitis C,
pubmed-meshheading:20538028-Humans,
pubmed-meshheading:20538028-Liver Neoplasms,
pubmed-meshheading:20538028-Male,
pubmed-meshheading:20538028-Menarche,
pubmed-meshheading:20538028-Middle Aged,
pubmed-meshheading:20538028-Parity,
pubmed-meshheading:20538028-Parturition,
pubmed-meshheading:20538028-Polymorphism, Single Nucleotide,
pubmed-meshheading:20538028-Pregnancy,
pubmed-meshheading:20538028-Premenopause,
pubmed-meshheading:20538028-Risk Factors,
pubmed-meshheading:20538028-Smoking,
pubmed-meshheading:20538028-Uterine Cervical Neoplasms
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.
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| pubmed:affiliation |
Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|