Linked Life Data

20537436

Source:http://linkedlifedata.com/resource/pubmed/id/20537436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-6-14
pubmed:abstractText
In the present work, we focused on quantification of activity of 3,4,6-substituted-2-quinolone derivatives with reference to structural properties. The multi-variant regression expressions were developed through sequential multiple linear regression technique, considering adjustable correlation coefficient (r(adj)(2)). The amalgamated best fit consensus scoring function showed coefficient of determination (0.891), leave one out cross validated squared correlation coefficient (0.776) and external predictivity value (0.668). The detailed structural investigation revealed that the FMS kinase inhibitory activity is predominantly explained by the topological descriptor, functional group, RDF and MoRSE code. The structural insights gleaned from the study could be usefully employed to design inhibitors with a much more enhanced potency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3472-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Insights through AM1 calculations into the structural requirement of 3,4,6-substituted-2-quinolone analogs towards FMS kinase inhibitory activity.
pubmed:affiliation
Department of Pharmaceutical Chemistry, Smriti College of Pharmaceutical Education, 4/1 Pipliya Kumar Kakad, Maya Kheri Road, Indore-452010, Madhya Pradesh, India. arunkg_73@hotmail.com
pubmed:publicationType
Journal Article