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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-7-7
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pubmed:abstractText |
G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to understand the characteristics of individual GPCRs and their subtypes. Previous phylogenetic classifications were all based on the sequences of receptors, adding only minor information about the ligand binding properties of the receptors. In this work, we compare a sequence-based classification of receptors to a ligand-based classification of the same group of receptors, and evaluate the potential to use sequence relatedness as a predictor for ligand interactions thus aiding the quest for ligands of orphan receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-11006272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12207082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12362358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12444729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12520006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12761335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12815157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-12836695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-1358127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-14761190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-15163592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-15588088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-15655528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-15914470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-16381955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-16539387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17125186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17300168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17375084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17396136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17477341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17488738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17533415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17942790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17952055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17962520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-17986454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-18045787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-18045790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-18594507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-18642350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-19434836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-19537715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-7786837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-8081729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-8709122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20537162-9177352
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
316
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization.
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pubmed:affiliation |
Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, 2333CC, The Netherlands. bendera@lacdr.leidenuniv.nl.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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