Source:http://linkedlifedata.com/resource/pubmed/id/20536911
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2010-11-9
|
| pubmed:abstractText |
Incompatibility of human leukocyte antigen (HLA) alleles between donors and recipients of unrelated hematopoietic stem cell transplantation (UHSCT) increases the risk of acute graft-versus-host disease (GVHD). We evaluated the positional effect of amino acid substitutions in HLA molecules on severe acute GVHD in Korean pediatric recipients of UHSCT. All of 64 donor-recipient pairs were serologically matched for HLA-A, -B, and -DR loci. Only substitution at residue 9 resulting from an HLA-A*02 polymorphism was significantly associated with the risk of severe acute GVHD in patients (OR=7.0, P=0.033) on multivariate analysis. Recipients of this mismatched HLA also showed shortened overall survival (HR=9.7, P<0.001) and increased risk for transplant-related mortality (HR=9.1, P=0.027). Structural modeling showed that the amino acid substitution could alter the peptide preference of the ligand-binding pocket. A single amino acid substitution at position 9 was a major predictor of severe acute GVHD in Korean pediatric patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1432-2277
|
| pubmed:author | |
| pubmed:copyrightInfo |
© 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1216-22
|
| pubmed:meshHeading |
pubmed-meshheading:20536911-Adolescent,
pubmed-meshheading:20536911-Amino Acid Sequence,
pubmed-meshheading:20536911-Amino Acid Substitution,
pubmed-meshheading:20536911-Asian Continental Ancestry Group,
pubmed-meshheading:20536911-Child,
pubmed-meshheading:20536911-Child, Preschool,
pubmed-meshheading:20536911-Female,
pubmed-meshheading:20536911-Graft vs Host Disease,
pubmed-meshheading:20536911-HLA-A2 Antigen,
pubmed-meshheading:20536911-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:20536911-Histocompatibility Testing,
pubmed-meshheading:20536911-Humans,
pubmed-meshheading:20536911-Infant,
pubmed-meshheading:20536911-Infant, Newborn,
pubmed-meshheading:20536911-Leukemia, Myeloid, Acute,
pubmed-meshheading:20536911-Logistic Models,
pubmed-meshheading:20536911-Male,
pubmed-meshheading:20536911-Models, Molecular,
pubmed-meshheading:20536911-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:20536911-Republic of Korea
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Impact of amino acid substitution at residue 9 of HLA-A2 on the development of acute GVHD in Korean pediatric patients receiving unrelated hematopoietic stem cell transplantation.
|
| pubmed:affiliation |
Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|