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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-6-11
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pubmed:abstractText |
Inflammatory cytokines including the IL-1 family, TNF-alpha and IL-6 mediate the formation of thrombosis on the luminal surface of atherosclerotic plaques. Gene polymorphisms that regulate these cytokines' expression may explain part of the variation in susceptibility to stroke in patients with carotid atherosclerosis. The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1747-4949
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-51
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pubmed:meshHeading |
pubmed-meshheading:20536609-Aged,
pubmed-meshheading:20536609-Atherosclerosis,
pubmed-meshheading:20536609-Carotid Arteries,
pubmed-meshheading:20536609-Cohort Studies,
pubmed-meshheading:20536609-DNA,
pubmed-meshheading:20536609-Female,
pubmed-meshheading:20536609-Genetic Markers,
pubmed-meshheading:20536609-Genetic Testing,
pubmed-meshheading:20536609-Haplotypes,
pubmed-meshheading:20536609-Humans,
pubmed-meshheading:20536609-Inflammation,
pubmed-meshheading:20536609-Interleukin-1,
pubmed-meshheading:20536609-Interleukin-6,
pubmed-meshheading:20536609-Leukocyte Count,
pubmed-meshheading:20536609-Linkage Disequilibrium,
pubmed-meshheading:20536609-Male,
pubmed-meshheading:20536609-Polymorphism, Single Nucleotide,
pubmed-meshheading:20536609-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20536609-Risk Factors,
pubmed-meshheading:20536609-Stroke,
pubmed-meshheading:20536609-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen.
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pubmed:affiliation |
National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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