20536404

Source:http://linkedlifedata.com/resource/pubmed/id/20536404

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007320, umls-concept:C0023884, umls-concept:C0025241, umls-concept:C0030705, umls-concept:C0035956, umls-concept:C0085973, umls-concept:C0087111, umls-concept:C0205373, umls-concept:C0268381, umls-concept:C0282441, umls-concept:C1831743
pubmed:issue	2
pubmed:dateCreated	2010-6-11
pubmed:abstractText	A 55-year-old woman with primary Immunoglobulin light chain (AL) systemic amyloidosis died due to spontaneous rupture of her liver following treatment with high-dose melphalan and autologous stem cell transplant (HDM/SCT). She was first diagnosed after developing nephrotic-range proteinuria. Spontaneous rupture of her liver occurred 10 days after treatment with HDM/SCT and was complicated by septic shock. She was not eligible for surgical intervention and died shortly after. Amyloid fibrils were extracted from the autopsied liver sample (05-135L) and the biochemical nature of the fibrils was analyzed using electrophoretic and immunohistochemical techniques. Our testing showed that the fibrils were composed of immunoglobulin lambda light chains that were not glycosylated. While the liver is often involved in AL amyloidosis, this is the first documented case of a spontaneous hepatic rupture in a patient during treatment with HDM/SCT. A literature review of spontaneous liver rupture in patients with amyloidosis is presented.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-01, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-010003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-02, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-020003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-030003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-040003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL068705-050003, http://linkedlifedata.com/resource/pubmed/grant/P01 HL68705
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-11468171, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-12439926, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-12904524, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-14530778, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-14734330, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-15106714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-15359415, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-15994597, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-16490898, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-16850379, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-1904284, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-3243230, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-3320489, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-3781175, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-454157, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-5806584, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-6202147, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-6302659, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-6600795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-7387282, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-7878478, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-8693415, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-8773388, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-9260817, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-9302305, http://linkedlifedata.com/resource/pubmed/commentcorrection/20536404-9729202
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9433802
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amyloid, http://linkedlifedata.com/resource/pubmed/chemical/Melphalan
pubmed:status	MEDLINE
pubmed:issn	1744-2818
pubmed:author	pubmed-author:ConnorsLawreen HLH, pubmed-author:ForbesBenjamin MBM, pubmed-author:OranBetulB, pubmed-author:QuillenKarenK, pubmed-author:SanchorawalaVaishaliV, pubmed-author:SeldinDavid CDC, pubmed-author:SkinnerMarthaM, pubmed-author:TamMartinM
pubmed:issnType	Electronic
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	103-7
pubmed:dateRevised	2010-9-30
pubmed:meshHeading	pubmed-meshheading:20536404-Amyloid, pubmed-meshheading:20536404-Amyloidosis, pubmed-meshheading:20536404-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:20536404-Fatal Outcome, pubmed-meshheading:20536404-Female, pubmed-meshheading:20536404-Humans, pubmed-meshheading:20536404-Immunohistochemistry, pubmed-meshheading:20536404-Liver Diseases, pubmed-meshheading:20536404-Melphalan, pubmed-meshheading:20536404-Middle Aged, pubmed-meshheading:20536404-Rupture, Spontaneous, pubmed-meshheading:20536404-Stem Cell Transplantation, pubmed-meshheading:20536404-Transplantation Conditioning
pubmed:year	2009
pubmed:articleTitle	Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature review.
pubmed:affiliation	Graduate Medical Sciences Division, Boston University School of Medicine, Boston, Massachusetts, USA.
pubmed:publicationType	Journal Article, Case Reports, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural