Linked Life Data

20534187

Source:http://linkedlifedata.com/resource/pubmed/id/20534187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-7-27
pubmed:abstractText
Calcium sulfate (CaSO(4)), as a commonly used implanting material, shows good biocompatibility, biodegradability, osteoconductivity and mechanical properties. Studies about using CaSO(4) as bone filler for the treatment of bone defects are reported now and then, but the fabrication of injectable implant was hardly studied. In this study, calcium sulfate hemihydrate (CSH), as the basic material, was incorporated with a cellulose derivative, poly(ethylene glycol) (PEG), calcium sulfate dehydrate (CSD) crystal coated with PEG (P-CSD), and a certain amount of water to form injectable CaSO(4) bone fillers. The structure of the bone fillers with different compositions was analyzed with scanning electron microscopy (SEM), infrared spectroscopy (IR) and X-ray diffraction (XRD). The effects of additives such as P-CSD, CSD, PEG and cellulose derivative on setting time, water absorption ability, mechanical properties and structure of the injectable bone fillers were studied. The in vitro degradation test showed that the injectable bone fillers have appropriate degradation time in phosphate-buffered solution (PBS), and they can maintain integrity throughout the degradation process. In vitro cell culture and preliminary animal model experiments demonstrated that the bone fillers do not exhibit a deleterious effect on cell viability and can hasten bone growth in bone defect model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1568-5624
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1313-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Fabrication of injectable calcium sulfate bone graft material.
pubmed:affiliation
School of Science, Tianjin University, Tianjin 300072, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't