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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-29
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pubmed:abstractText |
Molecular sensing in the gastro-intestinal (GI) tract is responsible for the detection of ingested harmful drugs and toxins, thereby genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of the gut in eliminating possible threats to the organism. Although these fundamental control systems have been known for long time, the initial molecular recognition events that sense the chemical composition of the luminal contents of the GI tract have remained elusive. TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-12379855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-12584440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-12679530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-14681826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-15178431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-15272419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-15297300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-15547448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-15810630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-16244653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-16298720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-16710053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17028303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17095755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17250611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17268246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17444812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-17596267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-18313914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20534144-20022913
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
pubmed-author:BaraleRobertoR,
pubmed-author:CampaDanieleD,
pubmed-author:CanzianFedericoF,
pubmed-author:CarraiMauraM,
pubmed-author:FörstiAstaA,
pubmed-author:HemminkiKariK,
pubmed-author:NaccaratiAlessioA,
pubmed-author:NovotnyJanJ,
pubmed-author:PardiniBarbaraB,
pubmed-author:VodickaPavelP,
pubmed-author:VodickovaLudmilaL
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20534144-Aged,
pubmed-meshheading:20534144-Case-Control Studies,
pubmed-meshheading:20534144-Colorectal Neoplasms,
pubmed-meshheading:20534144-European Continental Ancestry Group,
pubmed-meshheading:20534144-Female,
pubmed-meshheading:20534144-Gene Frequency,
pubmed-meshheading:20534144-Genetic Predisposition to Disease,
pubmed-meshheading:20534144-Humans,
pubmed-meshheading:20534144-Male,
pubmed-meshheading:20534144-Middle Aged,
pubmed-meshheading:20534144-Polymorphism, Genetic,
pubmed-meshheading:20534144-Receptors, G-Protein-Coupled,
pubmed-meshheading:20534144-Risk Factors,
pubmed-meshheading:20534144-Taste Buds
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pubmed:year |
2010
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pubmed:articleTitle |
A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer.
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pubmed:affiliation |
German Cancer Research Center (DKFZ), Heidelberg, Germany. d.campa@dkfz.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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