Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-6-21
pubmed:abstractText
Human immunodeficiency virus (HIV)-infected patients are at increased risk for development of pulmonary complications, including chronic obstructive pulmonary disease (COPD). Inflammation associated with subclinical infection has been postulated to promote COPD. Persistence of Pneumocystis is associated with HIV infection and COPD, although a causal relationship has not been established. We used a simian/human immunodeficiency virus model of HIV infection to study pulmonary effects of Pneumocystis colonization. Simian/human immunodeficiency virus-infected/Pneumocystis-colonized monkeys developed progressive obstructive pulmonary disease characterized by increased emphysematous tissue and bronchial-associated lymphoid tissue. Increased levels of T helper type 2 cytokines and proinflammatory mediators in bronchoalveolar lavage fluid coincided with Pneumocystis colonization and a decline in pulmonary function. These results support the concept that an infectious agent contributes to the development of HIV-associated lung disease and suggest that Pneumocystis colonization may be a risk factor for the development of HIV-associated COPD. Furthermore, this model allows examination of early host responses important to disease progression, thus identifying potential therapeutic targets for COPD.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-10051262, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-10351949, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-10691587, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-11014633, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-11067861, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-11734471, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-11751191, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-11897041, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-12200525, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-12599074, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-14607864, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-14736184, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15075515, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15117741, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15120396, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15215480, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15223864, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-1530827, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15516531, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15668323, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15699789, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15709053, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-15896800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-16236911, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-16670768, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-16751017, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-16842636, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-16907916, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17071833, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17099007, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17317735, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17400729, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17574286, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17578770, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-17878463, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18203142, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18259974, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18366326, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18410916, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18453359, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18488036, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-18515558, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-19014344, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-19038881, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-3512509, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-8484625, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-8779129, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-8794335, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-9167458, http://linkedlifedata.com/resource/pubmed/commentcorrection/20533880-9168232
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1537-6613
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
302-12
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
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