Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-6-10
pubmed:abstractText
Endothelial phenotypic heterogeneity plays an important role in the susceptibility of the cardiovascular system to disease. Arteries and heart valves are susceptible to chronic inflammatory disease in regions of blood flow disturbance that implicates hemodynamic forces and transport characteristics as prominent influences on endothelial phenotype. By combining in vivo high-throughput genomics (discovery science) and in vitro mechanistic approaches (reductionist science), we present endothelial patho-susceptibility as an imbalance of multiple interrelated pathways that sensitize the cells to pathological change. The recently identified association of endoplasmic reticulum stress with endothelium in regions of flow disturbance is outlined as an important example of susceptible phenotype linked to proinflammatory and oxidative stress pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1098-9064
pubmed:author
pubmed:copyrightInfo
Copyright (c) Thieme Medical Publishers.
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-75
pubmed:meshHeading
pubmed-meshheading:20533180-Adaptation, Physiological, pubmed-meshheading:20533180-Animals, pubmed-meshheading:20533180-Arteries, pubmed-meshheading:20533180-Atherosclerosis, pubmed-meshheading:20533180-Disease Susceptibility, pubmed-meshheading:20533180-Endoplasmic Reticulum, pubmed-meshheading:20533180-Endothelial Cells, pubmed-meshheading:20533180-Endothelium, Vascular, pubmed-meshheading:20533180-Gene Expression Profiling, pubmed-meshheading:20533180-Hemorheology, pubmed-meshheading:20533180-Humans, pubmed-meshheading:20533180-Hypercholesterolemia, pubmed-meshheading:20533180-Models, Biological, pubmed-meshheading:20533180-NF-kappa B, pubmed-meshheading:20533180-Oxidative Stress, pubmed-meshheading:20533180-Phenotype, pubmed-meshheading:20533180-Shear Strength, pubmed-meshheading:20533180-Swine, pubmed-meshheading:20533180-Unfolded Protein Response, pubmed-meshheading:20533180-Vasculitis
pubmed:year
2010
pubmed:articleTitle
Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.
pubmed:affiliation
Institute for Medicine and Engineering, Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. pfd@pobox.upenn.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural