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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-21
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GQ845124,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GQ845125,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GQ845126,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564221,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564222,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564223,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564224,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564225,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564226,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564227,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564228,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564229,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/GU564230
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pubmed:abstractText |
Guangxi is an important transit area for HIV transmission in South China. Characterization of the full-length genome of HIV-1 prevalent in the area is important for phylogenetic analysis and vaccine development. CRF01_AE is one of the most rapidly spreading subtypes in Guangxi. In this study, we reported thirteen near full-length CRF01_AE genomes from Guangxi, China. The nearly full-length genome was reverse transcripted and amplified in two halves with the 1-kb overlap regions. The PCR products were sequenced directly. The sequence analysis showed that all of 13 strains were CRF01_AE recombinant subtypes. Two clusters were set up with all of the sequences that grouped separately with sequences from Vietnam and Fujian, China, which strongly suggested multiple introductions of CRF01_AE strains into Guangxi province. The results will improve our understanding on the phylogenetic relationship of CRF01_AE strains in South China and also help in the development of a successful HIV vaccine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1931-8405
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pubmed:author |
pubmed-author:BaoZuoyiZ,
pubmed-author:ChenLiliL,
pubmed-author:JooFF,
pubmed-author:LiHanpingH,
pubmed-author:LiJingyunJ,
pubmed-author:LiangShujiaS,
pubmed-author:LiuSiyangS,
pubmed-author:LiuYongjianY,
pubmed-author:TomP APA,
pubmed-author:WangZhengZ,
pubmed-author:ZhuangDaominD
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-704
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pubmed:meshHeading |
pubmed-meshheading:20528151-Adult,
pubmed-meshheading:20528151-China,
pubmed-meshheading:20528151-Cluster Analysis,
pubmed-meshheading:20528151-Female,
pubmed-meshheading:20528151-Genotype,
pubmed-meshheading:20528151-HIV Infections,
pubmed-meshheading:20528151-HIV-1,
pubmed-meshheading:20528151-Humans,
pubmed-meshheading:20528151-Male,
pubmed-meshheading:20528151-Middle Aged,
pubmed-meshheading:20528151-Molecular Sequence Data,
pubmed-meshheading:20528151-Phylogeny,
pubmed-meshheading:20528151-Polymerase Chain Reaction,
pubmed-meshheading:20528151-RNA, Viral,
pubmed-meshheading:20528151-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20528151-Sequence Analysis, DNA,
pubmed-meshheading:20528151-Sequence Homology
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pubmed:year |
2010
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pubmed:articleTitle |
Genetic characterization of 13 subtype CRF01_AE near full-length genomes in Guangxi, China.
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pubmed:affiliation |
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Fengtai District, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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