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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-7
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pubmed:abstractText |
We explored multiple molecular mechanisms of the combination of docetaxel and an oncolytic prostate-restricted replication competent adenovirus (Ad) (PRRA) in advanced prostate cancer (PCa) models. The combinational therapy has potential to overcome the therapeutic limitations of poor virus distribution inside solid tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1521-2254
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
516-27
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pubmed:meshHeading |
pubmed-meshheading:20527044-Adenoviridae,
pubmed-meshheading:20527044-Animals,
pubmed-meshheading:20527044-Antigens, CD29,
pubmed-meshheading:20527044-Cell Death,
pubmed-meshheading:20527044-Cell Line, Tumor,
pubmed-meshheading:20527044-Enzyme Activation,
pubmed-meshheading:20527044-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20527044-Gene Therapy,
pubmed-meshheading:20527044-Genes, Reporter,
pubmed-meshheading:20527044-Genetic Vectors,
pubmed-meshheading:20527044-Humans,
pubmed-meshheading:20527044-Integrin beta3,
pubmed-meshheading:20527044-Male,
pubmed-meshheading:20527044-Neoplasm Transplantation,
pubmed-meshheading:20527044-Promoter Regions, Genetic,
pubmed-meshheading:20527044-Prostatic Neoplasms,
pubmed-meshheading:20527044-Taxoids,
pubmed-meshheading:20527044-Transgenes,
pubmed-meshheading:20527044-Virus Replication,
pubmed-meshheading:20527044-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Docetaxel increases antitumor efficacy of oncolytic prostate-restricted replicative adenovirus by enhancing cell killing and virus distribution.
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pubmed:affiliation |
Maine Institute for Human Genetics and Health, Bangor, ME, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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