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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-6-25
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pubmed:abstractText |
The ultra-short-acting neuromuscular blocker gantacurium is chemically degraded in vitro by rapid adduction of L-cysteine to its central olefinic double bond. Preliminary data have suggested that exogenous (intravenous) L-cysteine abolishes gantacurium blockade. Two new analogues of gantacurium (CW 002 and CW 011) have been synthesized to undergo slower L-cysteine adduction, yielding intermediate duration. L-cysteine adduction to and antagonism of these novel agents is further defined herein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkenes,
http://linkedlifedata.com/resource/pubmed/chemical/Atracurium,
http://linkedlifedata.com/resource/pubmed/chemical/CW 002,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Edrophonium,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Maleates,
http://linkedlifedata.com/resource/pubmed/chemical/Neostigmine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Blocking Agents,
http://linkedlifedata.com/resource/pubmed/chemical/cisatracurium,
http://linkedlifedata.com/resource/pubmed/chemical/gantacurium
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-1175
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
58-73
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pubmed:meshHeading |
pubmed-meshheading:20526187-Alkenes,
pubmed-meshheading:20526187-Animals,
pubmed-meshheading:20526187-Atracurium,
pubmed-meshheading:20526187-Chemical Processes,
pubmed-meshheading:20526187-Cholinesterase Inhibitors,
pubmed-meshheading:20526187-Chromatography, High Pressure Liquid,
pubmed-meshheading:20526187-Cysteine,
pubmed-meshheading:20526187-Dose-Response Relationship, Drug,
pubmed-meshheading:20526187-Drug Interactions,
pubmed-meshheading:20526187-Edrophonium,
pubmed-meshheading:20526187-Haplorhini,
pubmed-meshheading:20526187-Isoquinolines,
pubmed-meshheading:20526187-Macaca mulatta,
pubmed-meshheading:20526187-Male,
pubmed-meshheading:20526187-Maleates,
pubmed-meshheading:20526187-Neostigmine,
pubmed-meshheading:20526187-Neuromuscular Blockade,
pubmed-meshheading:20526187-Neuromuscular Blocking Agents,
pubmed-meshheading:20526187-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.
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pubmed:affiliation |
Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York 10065, USA. jjsavare@med.cornell.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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