Linked Life Data

20524847

Source:http://linkedlifedata.com/resource/pubmed/id/20524847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-12-16
pubmed:abstractText
Rhesus macaques (Macaca mulatta) are genetically similar to humans and share many characteristics of aging and age-related diseases. They age at approximately three times the rate of humans and develop spontaneous cancers. In both humans and rhesus macaques, cancer incidence increases with age with the greatest incidence in those over 60 years of age and 20 years, respectively. The current survey reports on the incidence of spontaneous neoplasia in two colonies of captive rhesus macaques: the Wisconsin National Primate Research Center colony with 28 years of records and a National Institute on Aging colony with 21 years of records. When categorized by organ and histologic diagnosis, the average age at diagnosis was greater than 20 years for all categories except oral squamous cell carcinoma. Neoplasms of the gastrointestinal system were the most commonly diagnosed, accounting for 48.8% of the cases. Adenocarcinomas of the large intestine were the most prevalent tumor identified. Although there are differences in the biological behavior of cancer in the rhesus macaque when compared with humans, they are a valuable model of comparative oncology.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1557-7716
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The incidence of spontaneous neoplasia in two populations of captive rhesus macaques (Macaca mulatta).
pubmed:affiliation
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715-1299, USA. hsimmons@primate.wisc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural