Linked Life Data

20523014

Source:http://linkedlifedata.com/resource/pubmed/id/20523014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-6-4
pubmed:abstractText
With specific reference to studies of growth hormone therapies, this chapter re-examines some basic principles in clinical research and considers some of the more complex aspects of trial design. The statistical structure which underpins trial design is characterized with specific attention given to samples size, subgroup analyses, multicentre trials and the role and implementation of randomization. Topics related to outcomes in studies of growth hormone therapy are discussed, including the possible value of surrogate responses, longitudinal outcomes and their analysis, and multiple outcomes. Additional design issues addressed are multiarmed trials, factorial designs and study monitoring. Brief comments are offered on the interpretation of negative trials and on non-inferiority trials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1662-2979
pubmed:author
pubmed:copyrightInfo
Copyright 2010 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-22
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Clinical trials: planning and analysis.
pubmed:affiliation
MRC Biostatistics Unit, Institute of Public Health, Cambridge, Cambridge, UK. vern.farewell@mrc-bsu.cam.ac.uk
pubmed:publicationType
Journal Article, Review