rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2010-8-4
|
pubmed:abstractText |
Acyl-coenzyme A: cholesterol acyltransferase1 (ACAT1) is an endoplasmic reticulum (ER)-resident enzyme that catalyzes the conversion of cholesterol into cholesteryl esters. We previously showed that cholesterol-loaded macrophages produce numerous ER-derived vesicles with elevated ACAT1 enzyme activity; some of these vesicles were shown to be closely associated with Golgi-related organelle(s). The aim of this study was to investigate the translocation of ACAT1 vesicle in cholesterol-loaded macrophages.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1880-3873
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
30
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
740-50
|
pubmed:dateRevised |
2011-7-1
|
pubmed:meshHeading |
pubmed-meshheading:20523008-Acetyl-CoA C-Acetyltransferase,
pubmed-meshheading:20523008-Animals,
pubmed-meshheading:20523008-Cells, Cultured,
pubmed-meshheading:20523008-Cholesterol,
pubmed-meshheading:20523008-Endoplasmic Reticulum,
pubmed-meshheading:20523008-Endosomes,
pubmed-meshheading:20523008-Esterification,
pubmed-meshheading:20523008-Humans,
pubmed-meshheading:20523008-Immunoblotting,
pubmed-meshheading:20523008-Lysosomal-Associated Membrane Protein 2,
pubmed-meshheading:20523008-Lysosomes,
pubmed-meshheading:20523008-Macrophages,
pubmed-meshheading:20523008-Mice,
pubmed-meshheading:20523008-Subcellular Fractions
|
pubmed:year |
2010
|
pubmed:articleTitle |
Association of ACAT1-positive vesicles with late endosomes/ lysosomes in cholesterol-rich human macrophages.
|
pubmed:affiliation |
Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|