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pubmed-article:20522258pubmed:dateCreated2010-6-4lld:pubmed
pubmed-article:20522258pubmed:abstractTextTo fulfill the model based drug development, the very first step is usually a model establishment from published literatures. Pharmacokinetics model is the central piece of model based drug development. This paper proposed an important approach to transform published non-compartment model pharmacokinetics (PK) parameters into compartment model PK parameters. This meta-analysis was performed with a multivariate nonlinear mixed model. A conditional first-order linearization approach was developed for statistical estimation and inference.lld:pubmed
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pubmed-article:20522258pubmed:statusMEDLINElld:pubmed
pubmed-article:20522258pubmed:issn1752-0509lld:pubmed
pubmed-article:20522258pubmed:authorpubmed-author:WangZhipingZlld:pubmed
pubmed-article:20522258pubmed:authorpubmed-author:LiLangLlld:pubmed
pubmed-article:20522258pubmed:authorpubmed-author:QuinneySara...lld:pubmed
pubmed-article:20522258pubmed:authorpubmed-author:ZhouJihaoJlld:pubmed
pubmed-article:20522258pubmed:authorpubmed-author:KimSeonghoSlld:pubmed
pubmed-article:20522258pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20522258pubmed:volume4 Suppl 1lld:pubmed
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pubmed-article:20522258pubmed:paginationS8lld:pubmed
pubmed-article:20522258pubmed:dateRevised2011-7-20lld:pubmed
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pubmed-article:20522258pubmed:year2010lld:pubmed
pubmed-article:20522258pubmed:articleTitleNon-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model.lld:pubmed
pubmed-article:20522258pubmed:affiliationDivision of Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46032, USA. zhipwang@iupui.edulld:pubmed
pubmed-article:20522258pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20522258pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:20522258pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:20522258pubmed:publicationTypeMeta-Analysislld:pubmed
pubmed-article:20522258pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed