Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-6-4
pubmed:abstractText
To fulfill the model based drug development, the very first step is usually a model establishment from published literatures. Pharmacokinetics model is the central piece of model based drug development. This paper proposed an important approach to transform published non-compartment model pharmacokinetics (PK) parameters into compartment model PK parameters. This meta-analysis was performed with a multivariate nonlinear mixed model. A conditional first-order linearization approach was developed for statistical estimation and inference.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-10783805, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-12606142, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-12762442, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-1315596, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-15286737, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-15298055, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-15358623, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-15637526, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-16353932, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-16702441, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-16972706, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-17522597, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-17885865, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-18991108, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-2242409, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-7618257, http://linkedlifedata.com/resource/pubmed/commentcorrection/20522258-8587036
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1752-0509
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S8
pubmed:dateRevised
2011-7-20
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model.
pubmed:affiliation
Division of Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46032, USA. zhipwang@iupui.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Meta-Analysis, Research Support, N.I.H., Extramural