Linked Life Data

20521808

Source:http://linkedlifedata.com/resource/pubmed/id/20521808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
2010-6-24
pubmed:abstractText
Polymer microgels of poly(vinyl alcohol)/poly(methacrylate-co-N-isopropyl acrylamide) showed a thermoresponsive behavior, suitable for application in drug delivery (Biomacromolecules 2009, 10, 1589). In this work molecular dynamics (MD) methods were used to explain which structural aspects are determining for thermoresponsivity and how water properties in the hydrogel are influenced. Two topologically different models of the junction domain in the hydrogel at the experimental hydration degree were studied at 293 and 323 K, below and above the transition temperature. MD simulations of the corresponding oligomers of poly(N-isopropyl acrylamide) were also performed for a comparison. Simulation results provided an atomic detailed description of the temperature induced modifications in the microgel network and of water dynamics, in agreement with available experimental findings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1520-5207
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8301-12
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Toward modeling thermoresponsive polymer networks: a molecular dynamics simulation study of N-isopropyl acrylamide co-oligomers.
pubmed:affiliation
Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Via della Ricerca Scientifica I, 00133 Rome, Italy. ester.chiessi@uniroma2.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't