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rdf:type |
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lifeskim:mentions |
umls-concept:C0014406,
umls-concept:C0015219,
umls-concept:C0032659,
umls-concept:C0035820,
umls-concept:C0042333,
umls-concept:C0057223,
umls-concept:C0086418,
umls-concept:C0262926,
umls-concept:C1332830,
umls-concept:C1708726,
umls-concept:C2004062
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pubmed:issue |
8
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pubmed:dateCreated |
2010-7-14
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pubmed:abstractText |
The transition from food collection to food production (FP) modified the nature of selective pressures, and several studies illustrate that genetic adaptation to new lifestyle has occurred in humans since the agricultural revolution. Here we test the hypothesis that high levels of genetic variation at CYP2D6, a locus coding for a detoxifying enzyme of the cytochrome P450 complex, reflect this change.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1744-6880
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-99
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pubmed:meshHeading |
pubmed-meshheading:20520586-African Continental Ancestry Group,
pubmed-meshheading:20520586-Cytochrome P-450 CYP2D6,
pubmed-meshheading:20520586-DNA, Mitochondrial,
pubmed-meshheading:20520586-Environment,
pubmed-meshheading:20520586-European Continental Ancestry Group,
pubmed-meshheading:20520586-Evolution, Molecular,
pubmed-meshheading:20520586-Genetic Loci,
pubmed-meshheading:20520586-Genetic Variation,
pubmed-meshheading:20520586-Genetics, Population,
pubmed-meshheading:20520586-Geography,
pubmed-meshheading:20520586-Haplotypes,
pubmed-meshheading:20520586-Humans,
pubmed-meshheading:20520586-Metabolic Detoxication, Drug,
pubmed-meshheading:20520586-Phenotype,
pubmed-meshheading:20520586-Phylogeny,
pubmed-meshheading:20520586-Species Specificity
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pubmed:year |
2010
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pubmed:articleTitle |
Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at human CYP2D6 locus.
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pubmed:affiliation |
Department of Biology and Evolution, University of Ferrara, Ferrara, Italy. silvia.fuselli@unife.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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