Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2010-6-3
pubmed:abstractText
Spinal cord injury can produce extensive long-term reorganization of the cerebral cortex. Little is known, however, about the sequence of cortical events starting immediately after the lesion. Here we show that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats. Besides the obvious loss of cortical responses to hindpaw stimuli (below the level of the lesion), cortical responses evoked by forepaw stimuli (above the level of the lesion) markedly increase. Importantly, these increased responses correlate with a slower and overall more silent cortical spontaneous activity, representing a switch to a network state of slow-wave activity similar to that observed during slow-wave sleep. The same immediate cortical changes are observed after reversible pharmacological block of spinal cord conduction, but not after sham. We conclude that the deafferentation due to spinal cord injury can immediately (within minutes) change the state of large cortical networks, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7528-37
pubmed:meshHeading
pubmed-meshheading:20519527-Afferent Pathways, pubmed-meshheading:20519527-Analysis of Variance, pubmed-meshheading:20519527-Animals, pubmed-meshheading:20519527-Biophysics, pubmed-meshheading:20519527-Disease Models, Animal, pubmed-meshheading:20519527-Electric Stimulation, pubmed-meshheading:20519527-Electroencephalography, pubmed-meshheading:20519527-Evoked Potentials, Somatosensory, pubmed-meshheading:20519527-Lidocaine, pubmed-meshheading:20519527-Lower Extremity, pubmed-meshheading:20519527-Male, pubmed-meshheading:20519527-Rats, pubmed-meshheading:20519527-Rats, Wistar, pubmed-meshheading:20519527-Sodium Channel Blockers, pubmed-meshheading:20519527-Somatosensory Cortex, pubmed-meshheading:20519527-Spinal Cord Injuries, pubmed-meshheading:20519527-Statistics as Topic, pubmed-meshheading:20519527-Tetrodotoxin
pubmed:year
2010
pubmed:articleTitle
Spinal cord injury immediately changes the state of the brain.
pubmed:affiliation
Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla-La Mancha, Toledo, Spain. jdaguilar@sescam.jccm.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural