rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
22
|
pubmed:dateCreated |
2010-6-3
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pubmed:abstractText |
Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/MH61285,
http://linkedlifedata.com/resource/pubmed/grant/MH68858,
http://linkedlifedata.com/resource/pubmed/grant/MH84051,
http://linkedlifedata.com/resource/pubmed/grant/P50 MH084051-01,
http://linkedlifedata.com/resource/pubmed/grant/P50 MH084051-02,
http://linkedlifedata.com/resource/pubmed/grant/P50 MH084051-03,
http://linkedlifedata.com/resource/pubmed/grant/P50 MH084051-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH061285-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH061285-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH061285-10,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH068858-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH068858-05
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1529-2401
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
2
|
pubmed:volume |
30
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
7466-72
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pubmed:dateRevised |
2011-6-2
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pubmed:meshHeading |
pubmed-meshheading:20519521-Adaptation, Psychological,
pubmed-meshheading:20519521-Adolescent,
pubmed-meshheading:20519521-Brain Mapping,
pubmed-meshheading:20519521-Child,
pubmed-meshheading:20519521-Child Abuse,
pubmed-meshheading:20519521-Child Behavior Disorders,
pubmed-meshheading:20519521-Diffusion Tensor Imaging,
pubmed-meshheading:20519521-Female,
pubmed-meshheading:20519521-Frontal Lobe,
pubmed-meshheading:20519521-Functional Laterality,
pubmed-meshheading:20519521-Humans,
pubmed-meshheading:20519521-Image Processing, Computer-Assisted,
pubmed-meshheading:20519521-Male,
pubmed-meshheading:20519521-Neuropsychological Tests,
pubmed-meshheading:20519521-Stress, Psychological
|
pubmed:year |
2010
|
pubmed:articleTitle |
Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk.
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pubmed:affiliation |
Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. jlhanson5@wisc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|