Linked Life Data

20517696

Source:http://linkedlifedata.com/resource/pubmed/id/20517696

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-31
pubmed:abstractText
An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1? expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-? expression showed the opposite. The synovial expression of MMP-1 and IL-1? showed a significant negative correlation with the severity of OA, while that of TGF-? again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1? expression in synovium decreased depending upon the severity of OA, while the TGF-? expression increased.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1432-5195
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
831-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis.
pubmed:affiliation
Department of Medicine for Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't