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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-2
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pubmed:abstractText |
A high incidence of thromboembolic events has been reported in patients with systemic lupus erythematosus (SLE). Phosphatidylserine (PS) is normally sequestered in the inner leaflet of cell membranes. Externalization of PS during cell activation is mediated by phospholipid scramblase 1 (PLSCR1) and has a central role in promoting blood coagulation. We investigated the underlying pathogenic status of thrombophilia in SLE by analyzing PLSCR1 expression on monocytes from patients with SLE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0315-162X
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pubmed:author |
pubmed-author:AmengualOlgaO,
pubmed-author:AtsumiTatsuyaT,
pubmed-author:FukushimaKazuakiK,
pubmed-author:HashimotoTokoT,
pubmed-author:HoritaTetsuyaT,
pubmed-author:IekoMasahiroM,
pubmed-author:KataokaHiroshiH,
pubmed-author:KoikeTakaoT,
pubmed-author:OkuKenjiK,
pubmed-author:SuzukiErikoE,
pubmed-author:YasudaShinsukeS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1639-45
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pubmed:meshHeading |
pubmed-meshheading:20516018-Adult,
pubmed-meshheading:20516018-Aged,
pubmed-meshheading:20516018-Antiphospholipid Syndrome,
pubmed-meshheading:20516018-Cell Membrane,
pubmed-meshheading:20516018-Exocytosis,
pubmed-meshheading:20516018-Female,
pubmed-meshheading:20516018-Fibrin,
pubmed-meshheading:20516018-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:20516018-Flow Cytometry,
pubmed-meshheading:20516018-Gene Expression,
pubmed-meshheading:20516018-Humans,
pubmed-meshheading:20516018-Lupus Erythematosus, Systemic,
pubmed-meshheading:20516018-Male,
pubmed-meshheading:20516018-Middle Aged,
pubmed-meshheading:20516018-Monocytes,
pubmed-meshheading:20516018-Phosphatidylserines,
pubmed-meshheading:20516018-Phospholipid Transfer Proteins,
pubmed-meshheading:20516018-Protein Isoforms,
pubmed-meshheading:20516018-RNA, Messenger,
pubmed-meshheading:20516018-RNA Splicing,
pubmed-meshheading:20516018-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Increased expression of phospholipid scramblase 1 in monocytes from patients with systemic lupus erythematosus.
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pubmed:affiliation |
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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