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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-1
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pubmed:abstractText |
Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are hallmarks of bronchial asthma. IL-5 is a critical cytokine for eosinophil maturation, survival, and mobilization. Attempts to target eosinophils for the treatment of asthma by means of IL-5 neutralization have only resulted in partial removal of airway eosinophils, and this warrants the development of more effective interventions to further explore the role of eosinophils in the clinical expression of asthma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6825
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pubmed:author |
pubmed-author:AnderssonCecilia KCK,
pubmed-author:BjermerLeifL,
pubmed-author:CoyleAnthony JAJ,
pubmed-author:Dall'acquaWilliam WWW,
pubmed-author:DamschroderMelissa MMM,
pubmed-author:ErjefaltJonas SJS,
pubmed-author:GossageDavidD,
pubmed-author:HumblesAlison AAA,
pubmed-author:KienerPeter APA,
pubmed-author:KoikeMasamichiM,
pubmed-author:KolbeckRolandR,
pubmed-author:KozhichAlexanderA,
pubmed-author:LiPengP,
pubmed-author:MackayCharles RCR,
pubmed-author:MolfinoNestor ANA,
pubmed-author:ReedJennifer LJL,
pubmed-author:SpitalnyGeorge LGL,
pubmed-author:StephensGeoffrey LGL,
pubmed-author:WoodsRobertR,
pubmed-author:WuHerrenH
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pubmed:copyrightInfo |
Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1344-1353.e2
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pubmed:meshHeading |
pubmed-meshheading:20513525-Animals,
pubmed-meshheading:20513525-Antibodies, Monoclonal,
pubmed-meshheading:20513525-Antibody Affinity,
pubmed-meshheading:20513525-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:20513525-Cell Count,
pubmed-meshheading:20513525-Eosinophils,
pubmed-meshheading:20513525-Epitope Mapping,
pubmed-meshheading:20513525-Epitopes,
pubmed-meshheading:20513525-Female,
pubmed-meshheading:20513525-Humans,
pubmed-meshheading:20513525-Interleukin-5 Receptor alpha Subunit,
pubmed-meshheading:20513525-Macaca fascicularis,
pubmed-meshheading:20513525-Male,
pubmed-meshheading:20513525-Mutagenesis, Site-Directed,
pubmed-meshheading:20513525-Protein Engineering,
pubmed-meshheading:20513525-Receptors, IgG,
pubmed-meshheading:20513525-Recombinant Fusion Proteins,
pubmed-meshheading:20513525-Surface Plasmon Resonance
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pubmed:year |
2010
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pubmed:articleTitle |
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.
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pubmed:affiliation |
Department of Respiratory, Inflammation & Autoimmunity, MedImmune, LLC, Gaithersburg, MD 20878, USA. KolbeckR@medimmune.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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