|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0004096,
umls-concept:C0031327,
umls-concept:C0036043,
umls-concept:C0205460,
umls-concept:C0441655,
umls-concept:C0547040,
umls-concept:C0597357,
umls-concept:C0681850,
umls-concept:C0920321,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1979963,
umls-concept:C2003903,
umls-concept:C2003941,
umls-concept:C2349001,
umls-concept:C2697811
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-6-1
|
|
pubmed:abstractText |
Increased eosinophil levels have been linked to airway inflammation and asthma exacerbations. IL-5 is responsible for eosinophil differentiation, proliferation, and activation; IL-5 receptors are expressed on eosinophils and their progenitors, and targeting such receptors induces eosinophil apoptosis.
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|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1097-6825
|
|
pubmed:author |
pubmed-author:BusseWilliam WWW,
pubmed-author:CoyleAnthony JAJ,
pubmed-author:GebaGregory PGP,
pubmed-author:GossageDavidD,
pubmed-author:KatialRohitR,
pubmed-author:KienerPeter APA,
pubmed-author:KoikeMasamichiM,
pubmed-author:KolbeckRolandR,
pubmed-author:MolfinoNestor ANA,
pubmed-author:SariSuhaS,
pubmed-author:SpitalnyGeorge LGL,
pubmed-author:WangBingB
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|
pubmed:copyrightInfo |
Copyright (c) 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
125
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1237-1244.e2
|
|
pubmed:meshHeading |
pubmed-meshheading:20513521-Adolescent,
pubmed-meshheading:20513521-Adult,
pubmed-meshheading:20513521-Antibodies, Monoclonal,
pubmed-meshheading:20513521-Apoptosis,
pubmed-meshheading:20513521-Asthma,
pubmed-meshheading:20513521-C-Reactive Protein,
pubmed-meshheading:20513521-Cell Count,
pubmed-meshheading:20513521-Eosinophil Cationic Protein,
pubmed-meshheading:20513521-Eosinophils,
pubmed-meshheading:20513521-Female,
pubmed-meshheading:20513521-Follow-Up Studies,
pubmed-meshheading:20513521-Humans,
pubmed-meshheading:20513521-Immunotherapy,
pubmed-meshheading:20513521-Interleukin-5 Receptor alpha Subunit,
pubmed-meshheading:20513521-Interleukin-6,
pubmed-meshheading:20513521-Lymphopenia,
pubmed-meshheading:20513521-Male,
pubmed-meshheading:20513521-Middle Aged,
pubmed-meshheading:20513521-Recombinant Fusion Proteins,
pubmed-meshheading:20513521-Respiratory Function Tests
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma.
|
|
pubmed:affiliation |
University of Wisconsin School of Medicine and Public Health, Madison, Wis., USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|
