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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-7-25
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pubmed:abstractText |
The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol.HCl to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3549
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-80
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pubmed:dateRevised |
2001-11-28
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pubmed:meshHeading |
pubmed-meshheading:2051326-Allosteric Regulation,
pubmed-meshheading:2051326-Chemistry, Pharmaceutical,
pubmed-meshheading:2051326-Delayed-Action Preparations,
pubmed-meshheading:2051326-Dialysis,
pubmed-meshheading:2051326-Hydrogen-Ion Concentration,
pubmed-meshheading:2051326-Kinetics,
pubmed-meshheading:2051326-Models, Chemical,
pubmed-meshheading:2051326-Polymethacrylic Acids,
pubmed-meshheading:2051326-Propranolol,
pubmed-meshheading:2051326-Solubility
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pubmed:year |
1991
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pubmed:articleTitle |
Propranolol:methacrylic acid copolymer binding interaction.
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pubmed:affiliation |
Pharmacy Research and Development, Wyeth-Ayerst Research, Rouses Point, NY 12979.
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pubmed:publicationType |
Journal Article
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