Source:http://linkedlifedata.com/resource/pubmed/id/20512710
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-6-30
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| pubmed:abstractText |
The cell wall of Saccharomyces cerevisiae can bind mycotoxins in vitro, but there is scarce information on whether this property decreases the absorption of mycotoxins in vivo. The effect of a yeast cell wall preparation (YCW) on toxicokinetics and balance excretion (urine and faeces) of aflatoxin B(1) (AFB1) and ochratoxin A (OTA) was tested in rats after oral administration of each toxin. The (3)H-labelled mycotoxins were used at low doses. Co-administration of YCW with AFB1 decreased the extent, but not the rate, of absorption. Concurrently, radioactivity excreted in faeces increased by up to 55% when compared with controls, whilst the excretion in urine decreased (p < 0.05). The effect of YCW on OTA was less marked, although it increased radioactivity excretion in faeces (up to 16%; p < 0.05) it did not result in changes in urine and toxicokinetic parameters. The in vivo effect is in agreement with the reported in vitro binding ability for these toxins (AFB1 > OTA). In conclusion, these results indicate that YCW could be used to protect monogastric animals against exposure to low dietary levels of selected mycotoxins.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aflatoxin B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Ochratoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Protective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/ochratoxin A
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1944-0057
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
27
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1153-60
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| pubmed:meshHeading |
pubmed-meshheading:20512710-Aflatoxin B1,
pubmed-meshheading:20512710-Animals,
pubmed-meshheading:20512710-Cell Extracts,
pubmed-meshheading:20512710-Cell Wall,
pubmed-meshheading:20512710-Dose-Response Relationship, Drug,
pubmed-meshheading:20512710-Drug Interactions,
pubmed-meshheading:20512710-Feces,
pubmed-meshheading:20512710-Food Contamination,
pubmed-meshheading:20512710-Half-Life,
pubmed-meshheading:20512710-Intestinal Absorption,
pubmed-meshheading:20512710-Male,
pubmed-meshheading:20512710-Ochratoxins,
pubmed-meshheading:20512710-Plasma,
pubmed-meshheading:20512710-Protective Agents,
pubmed-meshheading:20512710-Random Allocation,
pubmed-meshheading:20512710-Rats,
pubmed-meshheading:20512710-Rats, Sprague-Dawley,
pubmed-meshheading:20512710-Saccharomyces cerevisiae,
pubmed-meshheading:20512710-Urine
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| pubmed:year |
2010
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| pubmed:articleTitle |
Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation.
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| pubmed:affiliation |
INRA, UR1213 Herbivores, Site de Theix, F-63122 Saint Genès-Champanelle, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|