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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-7-28
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pubmed:abstractText |
Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from oxidative stress and apoptosis. Using transgenic mice that overproduce human TRX-1 (TRX-Tg mice), we examined whether oxidative stress is involved in fetal dysmorphogenesis in diabetic pregnancies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1432-0428
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pubmed:author |
pubmed-author:KamimotoYY,
pubmed-author:KihiraTT,
pubmed-author:MurabayashiNN,
pubmed-author:NagaoKK,
pubmed-author:PJ,
pubmed-author:SagawaNN,
pubmed-author:SugiyamaTT,
pubmed-author:ToyodaNN,
pubmed-author:UmekawaTT,
pubmed-author:YodoiJJ,
pubmed-author:ZhangLL
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2046-55
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pubmed:meshHeading |
pubmed-meshheading:20512310-Animals,
pubmed-meshheading:20512310-Apoptosis,
pubmed-meshheading:20512310-Diabetes Mellitus, Experimental,
pubmed-meshheading:20512310-Female,
pubmed-meshheading:20512310-Fetal Diseases,
pubmed-meshheading:20512310-Humans,
pubmed-meshheading:20512310-Immunohistochemistry,
pubmed-meshheading:20512310-Male,
pubmed-meshheading:20512310-Mice,
pubmed-meshheading:20512310-Mice, Inbred C57BL,
pubmed-meshheading:20512310-Mice, Transgenic,
pubmed-meshheading:20512310-Models, Biological,
pubmed-meshheading:20512310-Neuroepithelial Cells,
pubmed-meshheading:20512310-Polymerase Chain Reaction,
pubmed-meshheading:20512310-Pregnancy,
pubmed-meshheading:20512310-Pregnancy in Diabetics,
pubmed-meshheading:20512310-Thiobarbituric Acid Reactive Substances,
pubmed-meshheading:20512310-Thioredoxins
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pubmed:year |
2010
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pubmed:articleTitle |
Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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