Linked Life Data

20511386

Source:http://linkedlifedata.com/resource/pubmed/id/20511386

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-7-21
pubmed:abstractText
Surface properties play a vital role in the functioning of a biomaterial. Cellular adherence and growth onto biomaterials can be enhanced in biomaterial modifications of their surface. In this work, the cell behavior on chitosan membranes modified by argon and nitrogen-plasma treatments was investigated. Characterization of the membranes was performed using atomic force microscopy, contact angle measurements, and X-ray photoelectron spectroscopy. Cytotoxicity assessment and direct contact assay were carried out for untreated and treated chitosan membranes using L929 fibroblast-like cells. Cell morphology and cell viability were assessed to evaluate the cell attachment and proliferation. Changes in terms of roughness, surface chemistry, and hydrophilicity/hydrophobic balance of chitosan-modified membranes were observed. Regarding cell studies, the findings revealed that the extracts of all membranes do not induce cytotoxic effects. Moreover, the in vitro assays evidenced an improvement of the L929 adhesion and attachment when compared to untreated chitosan membranes. Overall, the data obtained clearly demonstrated that plasma treatments constitute an effective way of improving the biocompatibility of chitosan membranes towards to their use in biomedical applications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1530-8022
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-16
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Cell adhesion and proliferation onto chitosan-based membranes treated by plasma surface modification.
pubmed:affiliation
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine - AvePark, Zona Industrial da Gandra - Caldas das Taipas 4806-909, Guimarães, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't