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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9729
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid particles (SNALPs) completely protected guineapigs when administered shortly after a lethal ZEBOV challenge. Although rodent models of ZEBOV infection are useful for screening prospective countermeasures, they are frequently not useful for prediction of efficacy in the more stringent non-human primate models. We therefore assessed the efficacy of modified non-immunostimulatory siRNAs in a uniformly lethal non-human primate model of ZEBOV haemorrhagic fever.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1474-547X
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pubmed:author |
pubmed-author:GeisbertJoan BJB,
pubmed-author:GeisbertThomas WTW,
pubmed-author:HensleyLisa ELE,
pubmed-author:HonkoAnna NAN,
pubmed-author:JohnsonJoshua CJC,
pubmed-author:JudgeAdamA,
pubmed-author:LeeAmy C HAC,
pubmed-author:MaclachlanIanI,
pubmed-author:RobbinsMarjorieM,
pubmed-author:SoodVandanaV,
pubmed-author:TavakoliIranI,
pubmed-author:de JongSusanS
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
375
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1896-905
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pubmed:meshHeading |
pubmed-meshheading:20511019-Animals,
pubmed-meshheading:20511019-Cercopithecus aethiops,
pubmed-meshheading:20511019-Ebolavirus,
pubmed-meshheading:20511019-Female,
pubmed-meshheading:20511019-Hemorrhagic Fever, Ebola,
pubmed-meshheading:20511019-Infusions, Intravenous,
pubmed-meshheading:20511019-Interferon-alpha,
pubmed-meshheading:20511019-Interleukin-6,
pubmed-meshheading:20511019-Macaca mulatta,
pubmed-meshheading:20511019-Male,
pubmed-meshheading:20511019-Mice,
pubmed-meshheading:20511019-Mice, Inbred ICR,
pubmed-meshheading:20511019-RNA, Small Interfering,
pubmed-meshheading:20511019-RNA Interference,
pubmed-meshheading:20511019-Vero Cells,
pubmed-meshheading:20511019-Viral Proteins,
pubmed-meshheading:20511019-Viremia,
pubmed-meshheading:20511019-Virus Replication
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pubmed:year |
2010
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pubmed:articleTitle |
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study.
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pubmed:affiliation |
National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, MA 02118, USA. geisbert@bu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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