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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
Early clinical trials investigating the role of tightly controlled glucose levels showed marked benefit in survival of critically ill patients. However, a recent meta-analysis and large randomized controlled trial have failed to reproduce the benefit, showing instead substantially increased risk of dangerous hypoglycemia. We sought to investigate the effects of varying glucose concentrations on previously tested, prognostically significant, innate immune parameters, to define any potential effects of glucose at the cellular level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1879-1190
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
966-74
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pubmed:meshHeading |
pubmed-meshheading:20510806-Adolescent,
pubmed-meshheading:20510806-Adult,
pubmed-meshheading:20510806-Analysis of Variance,
pubmed-meshheading:20510806-Antigens, CD14,
pubmed-meshheading:20510806-Blood Glucose,
pubmed-meshheading:20510806-Critical Illness,
pubmed-meshheading:20510806-Cytokines,
pubmed-meshheading:20510806-Female,
pubmed-meshheading:20510806-Flow Cytometry,
pubmed-meshheading:20510806-HLA-DR Antigens,
pubmed-meshheading:20510806-Humans,
pubmed-meshheading:20510806-Hypoglycemia,
pubmed-meshheading:20510806-Immunity, Cellular,
pubmed-meshheading:20510806-Male,
pubmed-meshheading:20510806-Phagocytosis,
pubmed-meshheading:20510806-Reactive Oxygen Species,
pubmed-meshheading:20510806-Sepsis,
pubmed-meshheading:20510806-Surgical Procedures, Operative
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pubmed:year |
2010
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pubmed:articleTitle |
Glucose and surgical sepsis: a study of underlying immunologic mechanisms.
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pubmed:affiliation |
The Price Institute of Surgical Research, University of Louisville School of Medicine, 511 S. Floyd Street, Louisville, KY 40202, USA. m0qada01@louisville.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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