Source:http://linkedlifedata.com/resource/pubmed/id/20510490
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-8-23
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| pubmed:abstractText |
To try and identify potential parental risk factors for isolated non-syndromic metopic craniosynostosis, we did a telephone survey of parents of children who attended the craniofacial centre at Birmingham Children's Hospital (BCH), UK, from 1995 to 2004. We calculated the prevalence of a number of potential risk factors and compared them with those of the general population. A total of 103 children with syndromic or non-syndromic isolated metopic craniosynostosis were seen, of which 81 (79%) had non-syndromic, isolated metopic craniosynostosis (M:F ratio 3:1). The response rate to the telephone survey was 72%. The prevalences of maternal epilepsy and the use of valproate, antenatal maternal complications (hypertension or pre-eclampsia, haemorrhage, and urinary tract infection), and fertility treatment in our sample were significantly higher than among the general population (p=0.01 or less in all cases). The likely roles of maternal epilepsy and taking valproate in the aetiology of isolated non-syndromic metopic craniosynostosis are further consolidated by our study. The finding that antenatal complications are possible risk factors for craniosynostosis has not to our knowledge been published previously.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1532-1940
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
438-42
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| pubmed:meshHeading |
pubmed-meshheading:20510490-Anticonvulsants,
pubmed-meshheading:20510490-Chi-Square Distribution,
pubmed-meshheading:20510490-Craniosynostoses,
pubmed-meshheading:20510490-Epilepsy,
pubmed-meshheading:20510490-Female,
pubmed-meshheading:20510490-Fertility Agents, Female,
pubmed-meshheading:20510490-Great Britain,
pubmed-meshheading:20510490-Humans,
pubmed-meshheading:20510490-Male,
pubmed-meshheading:20510490-Pregnancy,
pubmed-meshheading:20510490-Pregnancy Complications,
pubmed-meshheading:20510490-Prenatal Exposure Delayed Effects,
pubmed-meshheading:20510490-Risk Factors,
pubmed-meshheading:20510490-Valproic Acid
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| pubmed:year |
2010
|
| pubmed:articleTitle |
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis.
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| pubmed:affiliation |
Oral and Maxillofacial Surgery, Leeds General Infirmary, LS1 3EX, Leeds, UK.
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| pubmed:publicationType |
Journal Article
|