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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-6-18
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pubmed:abstractText |
Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is aberrantly expressed in certain cancers. Given its role in chromatin remodeling and transcription regulation, we determined the effect of Reptin on the transcription of the telomerase reverse transcriptase (hTERT) gene, a key component of the telomerase complex and its expression in gastric cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20509972-10029071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20509972-10500096,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20509972-9973199
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/MYC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RUVBL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RUVBL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
132
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20509972-Carrier Proteins,
pubmed-meshheading:20509972-Cell Line, Tumor,
pubmed-meshheading:20509972-Chromatin Immunoprecipitation,
pubmed-meshheading:20509972-DNA Helicases,
pubmed-meshheading:20509972-Female,
pubmed-meshheading:20509972-Gene Expression,
pubmed-meshheading:20509972-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20509972-Gene Knockdown Techniques,
pubmed-meshheading:20509972-Humans,
pubmed-meshheading:20509972-Immunoblotting,
pubmed-meshheading:20509972-Immunohistochemistry,
pubmed-meshheading:20509972-Immunoprecipitation,
pubmed-meshheading:20509972-Promoter Regions, Genetic,
pubmed-meshheading:20509972-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:20509972-RNA, Small Interfering,
pubmed-meshheading:20509972-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20509972-Stomach Neoplasms,
pubmed-meshheading:20509972-Telomerase,
pubmed-meshheading:20509972-Transcription, Genetic,
pubmed-meshheading:20509972-Up-Regulation,
pubmed-meshheading:20509972-Uterine Cervical Neoplasms
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pubmed:year |
2010
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pubmed:articleTitle |
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer.
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pubmed:affiliation |
Department of Microbiology/Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine and School of Life Sciences, Shandong University, Jinan, PR China. jiajihui@sdu.edu.cn.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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