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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
Notch1 signaling has a critical function in maintaining a balance among cell proliferation, differentiation, and apoptosis. Our earlier work showed that the Notch1 intracellular domain interferes with the scaffolding function of c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP1), yet the effect of JIP1 for Notch1-recombining binding protein suppressor of hairless (RBP-Jk) signaling remains unknown. Here, we show that JIP1 suppresses Notch1 activity. JIP1 was found to physically associate with either intracellular domain of Notch1 or RBP-Jk and interfere with the interaction between them. Furthermore, we ascertained that JIP1 caused the cytoplasmic retention of RBP-Jk through an interaction between the C-terminal region of JIP1 including Src homology 3 domain and the proline-rich domain of RBP-Jk. We also found that RBP-Jk inhibits JIP1-mediated activation of the JNK1 signaling cascade and cell death. Our results suggest that direct protein-protein interactions coordinate cross-talk between the Notch1-RBP-Jk and JIP1-JNK pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin J Recombination...,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mapk8ip protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1476-5403
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pubmed:author |
pubmed-author:Dajas-BailadorFF,
pubmed-author:FellTT,
pubmed-author:GrafC JCJ,
pubmed-author:HanJ YJY,
pubmed-author:HongJ-AJA,
pubmed-author:HuJ-BJB,
pubmed-author:IVYE KEK,
pubmed-author:JungJJ,
pubmed-author:KEYY,
pubmed-author:KuoW TWT,
pubmed-author:NyeS WSW,
pubmed-author:ParkH-SHS,
pubmed-author:WhitmarshA JAJ,
pubmed-author:YoonJ-HJH
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1728-38
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pubmed:meshHeading |
pubmed-meshheading:20508646-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:20508646-Animals,
pubmed-meshheading:20508646-Apoptosis,
pubmed-meshheading:20508646-Blotting, Western,
pubmed-meshheading:20508646-Cell Differentiation,
pubmed-meshheading:20508646-Cell Proliferation,
pubmed-meshheading:20508646-DNA-Binding Proteins,
pubmed-meshheading:20508646-Fluorescent Antibody Technique,
pubmed-meshheading:20508646-Humans,
pubmed-meshheading:20508646-Immunoglobulin J Recombination Signal Sequence-Binding...,
pubmed-meshheading:20508646-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:20508646-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:20508646-MAP Kinase Signaling System,
pubmed-meshheading:20508646-Membrane Proteins,
pubmed-meshheading:20508646-Mice,
pubmed-meshheading:20508646-Mutagenesis, Site-Directed,
pubmed-meshheading:20508646-Protein Binding,
pubmed-meshheading:20508646-Protein Interaction Domains and Motifs,
pubmed-meshheading:20508646-Rats,
pubmed-meshheading:20508646-Receptor, Notch1,
pubmed-meshheading:20508646-Recombinant Proteins,
pubmed-meshheading:20508646-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway.
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pubmed:affiliation |
Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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