| pubmed-article:2050746 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0020440 | lld:lifeskim |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0376261 | lld:lifeskim |
| pubmed-article:2050746 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2050746 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2050746 | pubmed:dateCreated | 1991-7-25 | lld:pubmed |
| pubmed-article:2050746 | pubmed:abstractText | Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the brain (PS1) was 0.081 ml g-1 min-1 and the transport from the brain to the blood (PS2) was on the same order of magnitude. In hypercapnia, arterial pH decreased from 7.39 to 7.26 and PS1 to L-lactate increased significantly by 110%. PS2 also increased although a statistically significant difference compared to the resting state was not reached. It is concluded that L-lactate is easily taken up by the human brain, and that the mechanism by which it crosses the blood-brain barrier is equilibrative. Furthermore, the brain permeability to lactate is enhanced by hypercapnia and the mechanism is believed to act through the decrease in pH. | lld:pubmed |
| pubmed-article:2050746 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2050746 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2050746 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2050746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2050746 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2050746 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2050746 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2050746 | pubmed:issn | 0271-678X | lld:pubmed |
| pubmed-article:2050746 | pubmed:author | pubmed-author:HertzM MMM | lld:pubmed |
| pubmed-article:2050746 | pubmed:author | pubmed-author:PaulsonO BOB | lld:pubmed |
| pubmed-article:2050746 | pubmed:author | pubmed-author:KnudsenG MGM | lld:pubmed |
| pubmed-article:2050746 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2050746 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:2050746 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2050746 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2050746 | pubmed:pagination | 581-6 | lld:pubmed |
| pubmed-article:2050746 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:meshHeading | pubmed-meshheading:2050746-... | lld:pubmed |
| pubmed-article:2050746 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2050746 | pubmed:articleTitle | Kinetic analysis of the human blood-brain barrier transport of lactate and its influence by hypercapnia. | lld:pubmed |
| pubmed-article:2050746 | pubmed:affiliation | Department of Neurology, Rigshospitalet, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:2050746 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2050746 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2050746 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2050746 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2050746 | lld:pubmed |
