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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-12
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pubmed:abstractText |
Our previous study demonstrated that anti-double-stranded DNA (anti-dsDNA) antibodies involved in lupus nephritis down-regulate the production of interleukin-2 (IL-2) in T cells, which in turn, contributes to the defective production of cytotoxic cells and to activation-induced cell death in vitro. To reveal novel molecular targets for lupus therapy, the molecular mechanisms of IL-2 down-regulation by anti-dsDNA were studied.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2401-11
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pubmed:meshHeading |
pubmed-meshheading:20506162-Animals,
pubmed-meshheading:20506162-Antibodies, Monoclonal,
pubmed-meshheading:20506162-Autoantibodies,
pubmed-meshheading:20506162-Blotting, Western,
pubmed-meshheading:20506162-Cell Line,
pubmed-meshheading:20506162-Cells, Cultured,
pubmed-meshheading:20506162-DNA,
pubmed-meshheading:20506162-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20506162-Female,
pubmed-meshheading:20506162-Glomerulonephritis,
pubmed-meshheading:20506162-Humans,
pubmed-meshheading:20506162-Interleukin-2,
pubmed-meshheading:20506162-Lupus Erythematosus, Systemic,
pubmed-meshheading:20506162-Mice,
pubmed-meshheading:20506162-Mice, Inbred MRL lpr,
pubmed-meshheading:20506162-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20506162-Signal Transduction,
pubmed-meshheading:20506162-T-Lymphocytes
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pubmed:year |
2010
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pubmed:articleTitle |
Reversing interleukin-2 inhibition mediated by anti-double-stranded DNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice.
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pubmed:affiliation |
National Yang-Ming University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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