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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-27
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pubmed:abstractText |
SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and self-renewal. We have shown that Sall4 activates Oct4 and is a master regulator in murine ES cells. Other SALL gene members, especially Sall1 and Sall3 are expressed in both murine and human ES cells, and deletions of these two genes in mice lead to perinatal death due to developmental defects. To date, little is known about the molecular mechanisms controlling the regulation of expressions of SALL4 or other SALL gene family members.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-10051003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-10610715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-11688560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-12395297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-12843316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-15108323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-15282310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16086360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16518401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16670092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16763212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16790473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16840789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16978057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-16980957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-17038673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-17060609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-17093407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-17256792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-17940043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-18299846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-18454139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-18487508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-18804426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-19022762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-19060217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-19440552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20505821-9425907
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e10766
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20505821-Animals,
pubmed-meshheading:20505821-Binding Sites,
pubmed-meshheading:20505821-Cell Differentiation,
pubmed-meshheading:20505821-Cell Line,
pubmed-meshheading:20505821-DNA-Binding Proteins,
pubmed-meshheading:20505821-Embryonic Stem Cells,
pubmed-meshheading:20505821-Feedback, Physiological,
pubmed-meshheading:20505821-Gene Expression Regulation, Developmental,
pubmed-meshheading:20505821-Humans,
pubmed-meshheading:20505821-Mice,
pubmed-meshheading:20505821-Models, Genetic,
pubmed-meshheading:20505821-Multigene Family,
pubmed-meshheading:20505821-Octamer Transcription Factor-3,
pubmed-meshheading:20505821-Pluripotent Stem Cells,
pubmed-meshheading:20505821-Promoter Regions, Genetic,
pubmed-meshheading:20505821-Transcription, Genetic,
pubmed-meshheading:20505821-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells.
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pubmed:affiliation |
Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, Nevada, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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