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rdf:type |
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lifeskim:mentions |
umls-concept:C0014442,
umls-concept:C0017262,
umls-concept:C0038402,
umls-concept:C0038411,
umls-concept:C0054401,
umls-concept:C0080194,
umls-concept:C0086418,
umls-concept:C1171362,
umls-concept:C1257890,
umls-concept:C1515670,
umls-concept:C1520022,
umls-concept:C2348205
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pubmed:issue |
7
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pubmed:dateCreated |
1991-7-24
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pubmed:abstractText |
Specific proteolytic destruction of the human chemotaxin, C5a, is a property of group A and B streptococcal pathogens. Here we show that virulent group G streptococci from human sources also express C5a peptidase activity. The enzyme responsible for this activity is approximately the same size as and is antigenically similar to that produced by group A streptococci. On the basis of Southern hybridization analysis with an internal fragment of the group A C5a peptidase gene (scpA) as a probe, a copy of this gene was found in the genome of all group G human isolates tested. Comparison of partial restriction maps of scpA and scpG revealed significant similarity between the two genes. Group G strains isolated from dogs and cows were found to lack C5a peptidase activity and did not hybridize to the scpA-specific probe. The association of this activity with three streptococcal species suggests that elimination of phagocyte chemotactic attractants is a more universal virulence mechanism than originally anticipated.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-118929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-14103201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-14318053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-1984457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2172291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2404953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2406246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2443452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2445730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2542163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2687231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-2964038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3039012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3053900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-323487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3316991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3332910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3525415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-3905613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-4965052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-6089334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-6337096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-6416146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2050400-7037956
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:geneSymbol |
scpA,
scpG
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2305-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2050400-Adhesins, Bacterial,
pubmed-meshheading:2050400-Antigens, Bacterial,
pubmed-meshheading:2050400-Blotting, Southern,
pubmed-meshheading:2050400-Blotting, Western,
pubmed-meshheading:2050400-Chemotaxis, Leukocyte,
pubmed-meshheading:2050400-Cross Reactions,
pubmed-meshheading:2050400-DNA, Bacterial,
pubmed-meshheading:2050400-Endopeptidases,
pubmed-meshheading:2050400-Genes, Bacterial,
pubmed-meshheading:2050400-Humans,
pubmed-meshheading:2050400-Restriction Mapping,
pubmed-meshheading:2050400-Streptococcus
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pubmed:year |
1991
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pubmed:articleTitle |
Virulent human strains of group G streptococci express a C5a peptidase enzyme similar to that produced by group A streptococci.
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pubmed:affiliation |
Department of Microbiology, University of Minnesota, Minneapolis 55455.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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