rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2010-5-26
|
pubmed:abstractText |
Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties. We examined the biological effects of soy isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1097-0045
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
1
|
pubmed:volume |
70
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1127-33
|
pubmed:meshHeading |
pubmed-meshheading:20503397-Aged,
pubmed-meshheading:20503397-Aged, 80 and over,
pubmed-meshheading:20503397-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:20503397-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:20503397-Blotting, Western,
pubmed-meshheading:20503397-Cell Line, Tumor,
pubmed-meshheading:20503397-Curcumin,
pubmed-meshheading:20503397-Double-Blind Method,
pubmed-meshheading:20503397-Humans,
pubmed-meshheading:20503397-Isoflavones,
pubmed-meshheading:20503397-Male,
pubmed-meshheading:20503397-Middle Aged,
pubmed-meshheading:20503397-Prostate-Specific Antigen,
pubmed-meshheading:20503397-Prostatic Neoplasms,
pubmed-meshheading:20503397-Receptors, Androgen
|
pubmed:year |
2010
|
pubmed:articleTitle |
Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen.
|
pubmed:affiliation |
Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
|