Linked Life Data

2049882

Source:http://linkedlifedata.com/resource/pubmed/id/2049882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1991-7-19
pubmed:abstractText
Polypeptide hormones, recognized for their ability to regulate cell growth and differentiation, have been classified as growth factors. These growth factors have been extensively described in higher eukaryotic organisms and cell lines [Hedin and Westermark, Cell 37:9-20, 1984]. Here we report the identification and partial characterization of a putative growth factor present in vegetative amoebae of the cellular slime mold Dictyostelium discoideum. A mutant was selected and found to be temperature sensitive due to the absence of an extracellular protein suggestive of a growth factor. The putative growth factor (DGF) is a protein resistant to both heat and strong detergent treatment but sensitive to reducing agents. The physiological significance of DGF is as yet unknown. DGF is of interest both in relation to understanding the events which control cell proliferation in Dictyostelium and in its relationship to other known growth factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-253X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Evidence for the presence of a growth factor in Dictyostelium discoideum.
pubmed:affiliation
Dept. of Microbiology, SUNY, Stony Brook 11794.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.