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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2010-6-9
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pubmed:abstractText |
Persistently high plasma endothelin-1 (ET-1) levels in diabetic patients have been associated with the development of cardiac fibrosis, which results from the deposition of extracellular matrix and fibroblast recruitment from an as-yet unknown source. The underlying mechanism, however, remains elusive. Here, we hypothesize that ET-1 might contribute to the accumulation of cardiac fibroblasts through an endothelial-to-mesenchymal transition in diabetic hearts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AdiartoSukoS,
pubmed-author:AnggrahiniDyah WDW,
pubmed-author:EmotoNoriakiN,
pubmed-author:HirataKen-IchiK,
pubmed-author:IwasaNaokoN,
pubmed-author:KisanukiYaz YYY,
pubmed-author:MiyagawaKazuyaK,
pubmed-author:NakayamaKazuhikoK,
pubmed-author:RikitakeYoshiyukiY,
pubmed-author:SuzukiTakashiT,
pubmed-author:WidyantoroBambangB,
pubmed-author:YagiKeikoK,
pubmed-author:YanagisawaMasashiM
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2407-18
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pubmed:meshHeading |
pubmed-meshheading:20497976-Animals,
pubmed-meshheading:20497976-Aorta,
pubmed-meshheading:20497976-Cells, Cultured,
pubmed-meshheading:20497976-Diabetes Mellitus, Experimental,
pubmed-meshheading:20497976-Endothelin-1,
pubmed-meshheading:20497976-Endothelium, Vascular,
pubmed-meshheading:20497976-Fibroblasts,
pubmed-meshheading:20497976-Fibrosis,
pubmed-meshheading:20497976-Heart Rate,
pubmed-meshheading:20497976-Humans,
pubmed-meshheading:20497976-Mesenchymal Stem Cells,
pubmed-meshheading:20497976-Mice,
pubmed-meshheading:20497976-Mice, Knockout,
pubmed-meshheading:20497976-Umbilical Veins
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pubmed:year |
2010
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pubmed:articleTitle |
Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition.
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pubmed:affiliation |
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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