Linked Life Data

20497965

Source:http://linkedlifedata.com/resource/pubmed/id/20497965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Non-small-cell lung cancer (NSCLC) is a leading cause of malignancy-related mortality in the Western world. Despite advances in early detection and standard treatment, NSCLC is frequently diagnosed at an advanced stage and therefore patients have a poor prognosis. However, its heterogeneity provides ample opportunity for multiple treatment approaches and target pathways. Considerable progress has been made in identifying novel targets, leading to a growing number of treatment options. Overall survival (OS) may not always be the most appropriate primary end point for assessment of efficacy, as it is likely that patients with NSCLC will receive multiple lines of therapy during their treatment. Additionally, crossover appears as an ethical necessity to many investigators if molecular targeted agents display outstanding early efficacy. While improving OS remains the goal for clinicians, progression-free survival (PFS) is increasingly being utilised as an alternative end point. In this article, we will evaluate the value of PFS as a primary measure of efficacy for advanced NSCLC, compare the clinical situation with that in other solid malignancies and review the growing number of treatment options for NSCLC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1569-8041
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2324-32
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy?
pubmed:affiliation
Department of Medicine, Institut Gustave Roussy, Villejuif, France. Jean-Charles.Soria@igr.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Evaluation Studies