Linked Life Data

20497605

Source:http://linkedlifedata.com/resource/pubmed/id/20497605

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-8-11
pubmed:abstractText
Most neurons undergo their last cell division within the first 1 to 2% of the lifespan of an organism. This has been interpreted to mean that adult neurons are permanently postmitotic, but Alzheimer's disease (AD) is an example of a late-onset neurodegenerative disease that challenges this concept. In AD, neurons in populations at risk for death reactivate their cell cycle and replicate their genome - but rather than complete the cycle with mitosis and cytokinesis, the neurons die. While opening new perspectives on the etiology of AD dementia, the simple linear model suggested by this description gains in complexity with the maturation of the adult brain. This complexity makes the full understanding of the relationship between cell division and cell death more difficult to achieve. The quest for understanding is worthwhile, however, as fresh avenues for therapeutic intervention are the prizes for success.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1758-9193
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13
pubmed:dateRevised
2011-10-24
pubmed:year
2010
pubmed:articleTitle
The involvement of cell cycle events in the pathogenesis of Alzheimer's disease.
pubmed:affiliation
Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA. herrup@biology.rutgers.edu.
pubmed:publicationType
Editorial